J. Iran. Chem. Soc., Vol. 8, No. 4 December 2011, pp.965~972.

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The Synthesis of Chlorophyll-a Skeleton Homologs Bearing Linear Six-Carbon Chain from Methyl Pheophorbide-a

J.J. Wanga,*, G.F. Hanb and Y.K. Shimc

aScience and Engineering College of Chemistry and Biology, Yantai University, Yantai 264005, P. R. China
bSchool of Material Science and Engineering, Jiangsu University of Science and Technology, Zhenjiang, 212003, P.R. China
cSchool of Nano Engineering, Inji University, Gimhae, 621-749, South Korea

     The synthesis of chlorins bearing 6C-straight chain was accomplished from methyl pheophorbide-a. A series of chemical modifications were employed for the construction of active functional groups, such as bromine atom or aldehyde group, on the periphery of chlorins. These functionalized chlorins further reacted with the reagent containing straight carbon-chain by common chemical reactions to produce target compounds. The structures of all new chlorins were characterized by elemental analysis, IR, UV-Vis and 1H NMR spectra.

Keywords: Chlorophyll-a, Chlorin, Synthesis, Linear six-carbon chain, Photodynamic therapy (PDT)   

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