J. Iran. Chem. Soc., Vol. 8, No. 4 December 2011, pp.1135~1138.

Current location: JICS Archive > Vol. 8 > No. 4 > Articles : 28

Synthesis of Two New Heterocyclic Systems: Furo[3',2':5,6]pyrimido[2,1-c][1,2,4]triazines and Furo[3,2-e][1,2,3,4]tetrazolo[1,5-a]pyrimidine

M. Rahimizadeha,*, M. Bakavolia, Z. Gordia,b and S.M. Seyedia

aDepartment of Chemistry, Ferdowsi University of Mashhad, Mashhad 91775-1436, Iran
bDepartment of Chemistry, Payame Noor University (PNU), Torbat-e-Heydarieh, Iran

     Two novel heterocyclic triazines and tetrazole systems were synthesized through cyclization of 2-hydrazino-furo[2,3-d]pyrimidine with α-haloketones and nitrous acid respectively in high yields. The starting 2-hydrazino-pyrimidine was synthesized from 4-imino-3,6-diphenyl-furo[2,3-d]pyrimidine-2(1H)-thione by methylation and subsequent nucleophilic displacement of methylthio group with hydrazine hydrate.

Keywords: Furo[2,3-d]pyrimidine, α-Haloketones, Triazines, Tetrazole

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