J. Iran. Chem. Soc., Vol. 6, No. 3 September 2009, pp.638~646.

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Potassium peroxydisulfate as an Efficient Oxidizing Agent for Conversion of Ethyl 3,4-Dihydropyrimidin-2(1H)-one-5-carboxylates to their Corresponding Ethyl Pyrimidin-2(1H)-one-5-carboxylates

H.R. Memarian* and A. Farhadi

Department of Chemistry, Faculty of Science, University of Isfahan, 81746-73441, Isfahan, Iran

Various ethyl 3,4-dihydropyrimidin-2(1H)-one-5-carboxylates were oxidized to their corresponding ethyl pyrimidin-2(1H)-one-5-carboxylates by potassium peroxydisulfate in refluxing aqueous acetonitrile. The products were obtained in good to excellent yields. The effect of the nature of 4-substituent and also the nature of solvent play an important role on the rate of oxidation.

Keywords: Dihydropyrimidinone, Oxidation, Pyrimidinone, Potassium peroxydisulfate, Substituent effect

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