J. Iran. Chem. Soc., Vol. 6, No. 2 June 2009, pp.300~309.

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Synthesis, Characterization, Biological and Thermal Studies of Cu(II) Complexes of Salen and Tetrahedrosalen Ligands

H. Khanmohammadia,*, M. Salehifarda and M.H. Abnosib

aDepartment of Chemistry, Arak University, Arak 38156, Iran
bDepartment of Biology, Arak University, Arak 38156, Iran

A series of mononuclear salen type copper(II) complexes, [CuLn] (n = 1-4), and their corresponding tetrahydrosalen complexes, [CuH2Ln] (n = 1,2) were prepared by the reaction of the N2O2 ligands with Cu(II) ion in ethanol, where H2L1 = N,N-bis(3,5-di-tert-butylsalicylidene)-2,2-dimethyle-1,3-diaminopropan, H2L2 = N,N-bis(3,5-di-tert-butylsalicylidene)-1,2-diamino-propane, H2L3 = N,N-bis(4-methoxysalicylidene)-2,2-dimethyle-1,3-diaminopropan; H2L4 = N,N-bis(4-methoxysalicylidene)-1,2-diaminopropane, H2[H2L1] = N,N-bis(2-hydroxyl-3,5-di-tert-butylphenyl)-2,2-dimethyle-1,3-diaminopropan and H2[H2L2] = N,N-bis(2-hydroxyl-3,5-di-tert-butylphenyl)-1,2-diaminopropane. The prepared ligands and complexes were characterized by the combination of IR, UV-Vis, NMR (as far as possible), elemental and thermal analyses. All prepared compounds were also evaluated for their antibacterial (Escherichia coli and Staphylococcus aureus) and antifungal (Candida albicans) activities by the disc diffusion method. The compounds were found have no remarkable antimicrobial activities.

Keywords: Cu(II) complex, Salen, Schiff base, Thermal analysis, Biological activity

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