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Article info. : 2006; 3(3) (pp 272~276)


Synthesis and in vitro Cytotoxicity Studies of Novel Triazolo[4,3-b]pyridazinones

E.M. Rakiba,* , S. Abourichaa,b, A. Hanniouia, N. Benchatb, L. Ait M’barekc and A. Zyadc

aLaboratory of Organic and Analytical Chemistry, Faculty of Sciences and Techniques, Beni-Mellal, Morocco
bDepartment of Chemistry, Faculty of Sciences, University Mohammed I, Oujda, Morocco
cLaboratory of Immunological, Biochemical and Molecular Biology, Faculty of Sciences and Techniques, Beni-Mellal, Morocco

(Received 10 March 2006, Accepted 8 June 2006)

New triazolo[4,3-b]pyridazinones were synthesized and evaluated for their potential in vitro cytotoxic antitumor properties. The compounds were prepared by 1,3-dipolar cycloaddition of pyridazin-3-ones with N-aryl-C-ethoxycarbonylnitrile imines, generated in situ from ethylhydrazono-a -bromoglyoxylates. The peri- and regioselectivity of the reaction were ascertained by 1H and 13C NMR spectroscopy of the cycloadducts.

Keywords: Triazolo[4,3-b]pyridazinones, Cycloaddition, Cytotoxicity, Hep cells


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