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Article info. : 2006; 3(3) (pp 272~276)

Synthesis and in vitro Cytotoxicity Studies of Novel Triazolo[4,3-b]pyridazinones

E.M. Rakib^a,*, S. Abouricha^a,b, A. Hannioui^a, N. Benchat^b, L. Ait M’barek^c and A. Zyad^c

^{aLaboratory of Organic and
Analytical Chemistry, Faculty of Sciences and Techniques, Beni-Mellal,
Morocco

^bDepartment of Chemistry, Faculty of Sciences, University
Mohammed I, Oujda, Morocco

^cLaboratory of Immunological, Biochemical and Molecular Biology,
Faculty of Sciences and Techniques, Beni-Mellal, Morocco

(Received 10 March 2006, Accepted 8 June 2006)

New triazolo[4,3-b]pyridazinones
were synthesized and evaluated for their potential in vitro cytotoxic
antitumor properties. The compounds were prepared by 1,3-dipolar
cycloaddition of pyridazin-3-ones with N-aryl-C-ethoxycarbonylnitrile
imines, generated in situ from ethylhydrazono-a -bromoglyoxylates.
The peri- and regioselectivity of the reaction were ascertained by ¹H
and ¹³C NMR spectroscopy of the cycloadducts.

Keywords:
Triazolo[4,3-b]pyridazinones, Cycloaddition, Cytotoxicity, Hep cells}