Journal of the Iranian Chemical Society (JICS)
Published by the Iranian Chemical Society P.O.Box: 13145-887, Tehran, Iran Tel: (+98) 21 66908032-33 Fax: (+98) 21 66908030
Home About Editorial Board Instructions to Authors Subscription Archive Submission Feedback
Quick Search 

Article info. : 2006; 3(3) (pp 233~241)


Neat Reaction Technology for the Synthesis of 4-Oxo-thiazolidines Derived from 2-SH-Benzothiazole and Antimicrobial Screening of Some Synthesized 4-Thiazolidinones

K.G. Desai a,*, J.P. Ravalb and K.R. Desaic

aDepartment of Chemistry, Faculty of Science, Synthetic Organic Chemistry Research Laboratory,
Veer Narmad South Gujarat University, Surat, Gujarat State, India
bIndustrial Chemistry Division, Department of Chemistry, V.N.S.G. University, Surat, Gujarat State, India
cChemistry Department, Organic Chemistry Division, Faculty of Science, V. N.S.G. University, Surat, Gujarat State, India

This paper is dedicated to Prof. K.R. Desai in recognition of his outstanding contributions to "Green Chemistry"

(Received 8 April 2006, Accepted 2 May 2006)

The synthesis of 4-thiazolidinones 4a-j in a good yields from the heterocyclization reaction of 2-(benzothiazol-2-ylthio)-N'-benzylideneacetohydrazide 3a-j with SHCH2COOH in DMF in the presence of a catalytic amount of anhydrous ZnCl2 under microwave irradiation is described and compared with conventional synthesis methods. All structures of the newly synthesized compounds were elucidated by elemental analysis and spectral data. Some of the new compounds were tested against bacteria (Gram– ve and Gram+ ve) and fungi. 

Keywords: 4-Thiazolidinones, Heterocyclization, Microwave effect, Antimicrobial activity


2005 © Copyright JICS , Iranian Chemical Society