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Article info. : 2006; 3(3) (pp 233~241)

Neat Reaction Technology for the Synthesis of 4-Oxo-thiazolidines Derived from 2-SH-Benzothiazole and Antimicrobial Screening of Some Synthesized 4-Thiazolidinones^†

K.G. Desai^a,*, J.P. Raval^b and K.R. Desai^c

^{aDepartment of
Chemistry, Faculty of Science, Synthetic Organic Chemistry Research
Laboratory,

Veer Narmad South Gujarat University, Surat, Gujarat State, India

^bIndustrial Chemistry Division, Department of Chemistry, V.N.S.G.
University, Surat, Gujarat State, India

^cChemistry Department, Organic Chemistry Division, Faculty of
Science, V. N.S.G. University, Surat, Gujarat State, India

†This paper is dedicated to
Prof. K.R. Desai in recognition of his outstanding contributions to "Green
Chemistry"

(Received 8 April 2006, Accepted 2 May 2006)

The synthesis of 4-thiazolidinones 4a-j in a good
yields from the heterocyclization reaction of 2-(benzothiazol-2-ylthio)-N'-benzylideneacetohydrazide
3a-j with SHCH₂COOH
in DMF in the presence of a catalytic amount of anhydrous ZnCl₂
under microwave irradiation is described and compared with conventional
synthesis methods. All structures of the newly synthesized compounds were
elucidated by elemental analysis and spectral data. Some of the new
compounds were tested against bacteria (Gram– ve and Gram+ ve)
and fungi.

Keywords:
4-Thiazolidinones, Heterocyclization, Microwave effect,
Antimicrobial activity}