One-Pot Facile Conversion of Baylis-Hillman Adducts into 1,5-Diarylpyrazoles Using Microwave Irradiation

M. Mamaghani*, K. Tabatabaeian, M. Mirzaeinejad and M. Nikpassand

Department of Chemistry, Faculty of Sciences,University of Guilan,

Rasht, Iran

(Received 8 November 2005, Accepted 11 January 2006)

      Several Baylis-Hillman adducts were prepared by the reaction of appropriate arylaldehydes with methyl vinyl ketone in the presence of imidazole and a catalytic amount of L-proline, in 55-90% yields. An easy transformation of these adducts into 1,5-diarylpyrazoles was achieved using microwave irradiation (400 W) with short reaction times (1-3 min) and high yields (80-91%).

Keywords: Baylis-Hillman, 1,5-Diarylpyrazole, Microwave