One-Pot Facile Conversion of Baylis-Hillman Adducts into 1,5-Diarylpyrazoles Using Microwave Irradiation
M. Mamaghani*, K. Tabatabaeian, M. Mirzaeinejad and M. Nikpassand
Department of Chemistry, Faculty of Sciences,University of Guilan,
(Received 8 November 2005, Accepted 11 January 2006)
Several Baylis-Hillman adducts were prepared by the reaction of appropriate arylaldehydes with methyl vinyl ketone in the presence of imidazole and a catalytic amount of L-proline, in 55-90% yields. An easy transformation of these adducts into 1,5-diarylpyrazoles was achieved using microwave irradiation (400 W) with short reaction times (1-3 min) and high yields (80-91%).
Keywords: Baylis-Hillman, 1,5-Diarylpyrazole, Microwave