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Article info. : 2005; 2(4) (pp 244~337)


Organotin(IV) Derivatives as Biocides: An Investigation of Structure by IR,  Solution NMR, Electron Impact MS and Assessment of Structure Correlation with Biocidal Activity

S. Shahzadia, K. Shahida, S. Alia,*, M. Mazhara and K.M. Khanb

aDepartment of Chemistry, Quaid-i-Azam University, 45320-Islamabad, Pakistan
bH.E.J. Research Institute of Chemistry, University of Karachi, 75270-Karachi, Pakistan

(Received 13 June 2005, Accepted 14 September 2005)

A brief account is given of the synthesis, structural chemistry and the antibacterial, antifungal and cytotoxic effects of organotin complexes of 2-[(2,4-dichloroanilinocarbonyl)]benzoic acid. The unimolar and bimolar substitution products have been characterized by elemental analysis and spectral studies, including IR, 1H NMR, 13C NMR, 119Sn NMR, and mass spectra. The data support the binding of the oxygen atom to the tin atom in [R2Sn(OOCR/)2] and [R3Sn(OOCR/)] (R = Me, Bu, and Ph, R/ = 2-[(2,4-dichloroanilinocarbonyl)]benzoic acid). Based on these studies, with a coordination number of four, a distorted tetrahedral geometry has been proposed for the resulting derivatives in solution. The free ligand (R/COOH) and its respective tin complexes were tested in vitro against a number of microorganisms to assess their biocidal properties and to correlate them with the structures of the derivatives.

Keywords: Structure correlation, Biocidal activity, Organotin(IV) complexes, Spectroscopic analysis


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