Betting Sites Not On GamstopBest Non Gamstop Casinos 2025Kasino OnlineCasino Not On GamstopNon Gamstop CasinosSiti Casino Non Aams
Journal of the Iranian Chemical Society (JICS)
Published by the Iranian Chemical Society P.O.Box: 13145-887, Tehran, Iran Tel: (+98) 21 66908032-33 Fax: (+98) 21 66908030
Home About Editorial Board Instructions to Authors Subscription Archive Submission Feedback
Quick Search

Article info. : 2004; 1(1) (pp 33~39)

Facile Entries for Regioselective Synthe sis of [1,2,4]Triazolo- [4,3-a]pyrimidin-5(1H)-ones from 2-Thiouracil

A.S. Shawalia,*, I.M. Abbasa and A.M. Mahranb

a Department of Chemistry, Faculty of Science, University of Cairo,Giza,Egypt b National Research Centre, Dokki, Giza, Egypt

Three new alternative synthetic strategies� based on reactions of hydrazonoyl halides 3 with 2-methylthiouracil 2 and treatment of either 2 -pyrimidinyl thiohydrazonates 8 or the diazonium coupling products of active (pyrimidin-2-ylthio)methylene compounds 12 with sodium ethoxide in ethanol are described for the title compounds. The mechanisms and regiochemistry of the studied reactions are discussed.

Keywords: Heterocycles, Hydrazones, Rearrangement, Synthetic methods, 1,2,4-Triazolo-pyrimidine

2005 � Copyright JICS , Iranian Chemical Society