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Synthesis and Biological Study of Novel Bis-chalcones,
Bis-thiazines and Bis- pyrimidines
A. Nagaraj and C. Sanjeeva Reddy*
Department of Chemistry, Kakatiya
University, Warangal-506009, Andhra Pradesh, India
(Received 19 July 2007, Accepted 5 August 2007)
A series of
novel bis-chalcones 3 were prepared by the reaction of
5,5’-methylene-bis-salicylaldehyde 2 with various acetophenones,
subsequent treatment of 3 with thiourea or guanidine resulted to
the corresponding bis-thiazines or bis-pyrimidines in good yields. All
the new compounds have been characterized by IR, 1H NMR, MS
and elemental analysis. The antibacterial, antifungal and
anti-inflammatory activities of the compounds have also been evaluated.
Keywords:
Bis-chalcones,
Bis-thiazines,
Bis-pyrimidines,
5,5’-Methylene-bis-salicylaldehyde
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