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Article info. : 2008; 5(2) (pp 262~267)


Synthesis and Biological Study of Novel Bis-chalcones, Bis-thiazines and Bis- pyrimidines

A. Nagaraj and C. Sanjeeva Reddy*

Department of Chemistry, Kakatiya University, Warangal-506009, Andhra Pradesh, India

(Received 19 July 2007, Accepted 5 August 2007)

A series of novel bis-chalcones 3 were prepared by the reaction of 5,5-methylene-bis-salicylaldehyde 2 with various acetophenones, subsequent treatment of 3 with thiourea or guanidine resulted to the corresponding bis-thiazines or bis-pyrimidines in good yields. All the new compounds have been characterized by IR, 1H NMR, MS and elemental analysis. The antibacterial, antifungal and anti-inflammatory activities of the compounds have also been evaluated.

Keywords: Bis-chalcones, Bis-thiazines, Bis-pyrimidines, 5,5-Methylene-bis-salicylaldehyde



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