Journal of the Iranian Chemical Society (JICS)

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Article info. : 2008; 5(2) (pp 238~243)


Synthesis and Kinetic Resolution of Furyl Substituted Secondary Carbinols by Porcine Pancreatic Lipase under Solvent Free Conditions

M. Mamaghani*, N.O. Mahmoodi, A.A. Moghisseh and L. Pourmohamad

Department of Chemistry, Faculty of Sciences ,The University of Guilan, P.O. Box 41335-1914, Rasht, Iran

(Received 20 December 2006, Accepted 27 July 2007)

Chiral furyl substituted carbinols were prepared from the related carbonyl compounds and their enzymatic kinetic resolution was studied by using porcine pancreatic lipase (PPL) in transesterification reaction under solvent free condition. This study revealed that carbinols having one less bulky group on the chiral center are good substrates for PPL and the resolution proceeds with higher ee,s and less reaction time.

Keywords: Synthesis, Kinetic resolution, Porcine pancreatic lipase, Chiral furyl carbinols, Solvent free


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