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Article info. : 2007; 4(2) (pp 229~237)
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Michael Addition of Phthalimide and Saccharin to α,β-Unsaturated Esters Under Solvent-Free Conditions G.H. Imanzadeha,*, A. Khalafi-Nezhadb,*, A. Zarec,*,�A. Hasaninejad, A.R. Moosavi Zarea,�A. Parhamib aDepartment of Chemistry, Faculty of Basic Sciences, Mohagheghe Ardebili University, Ardebil 179, Iran bDepartment of Chemistry, College of Sciences, Shiraz University, Shiraz 71454, Iran cDepartment of Chemistry, Payame Nour University of Bushehr, Bushehr 1698, Iran (Received 19 October 2006, Accepted 31 December 2006) � An efficient, clean and simple procedure for the Michael addition of phthalimide and saccharin to various a ,b -unsaturated esters in the presence of tetrabutylammonium bromide (TBAB) and 1,4-diazabicyclo[2,2,2]octane (DABCO) under solvent-free conditions is described. By this method, the Michael adducts are obtained in good to excellent yields in short reaction times under thermal and microwave conditions. Keywords: Michael addition, Phthalimide, Saccharin, �,�-Unsaturated esters, Solvent-free |
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