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Article info. : 2007; 4(2) (pp 194~198)


Reductive Amination of Aldehydes with Sodium Borohydride and Lithium Aluminum Hydride in the Presence of Lithium Perchlorate

M.R. Saidia,*, R. Stan Brownb,* and A. Ziyaei-Halimjania

bDepartment of Chemistry, Queen’s University, Kingston, Ontario, Canada

aDepartment of Chemistry, Department of Chemistry, Sharif University of Technology,

P.O. Box 11365-9516 Tehran, Iran

(Received 6 October 2006, Accepted 12 November 2006)

A one-pot high yielding reductive amination of aldehydes with primary and secondary amines using LiClO4/NaBH4 and LiClO4/LiAlH4 as reducing agents in diethyl ether is described.

Keywords: Reductive amination, Sodium borohydride, Lithium aluminum hydride, Lithium perchlorate, Aldehyde


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