Reductive Amination of Aldehydes with Sodium Borohydride and Lithium Aluminum Hydride in the Presence of Lithium Perchlorate
M.R. Saidia,*, R. Stan Brownb,* and A. Ziyaei-Halimjania
bDepartment of Chemistry, Queen’s University, Kingston, Ontario, Canada
aDepartment of Chemistry, Department of Chemistry, Sharif University of Technology,
P.O. Box 11365-9516 Tehran, Iran
(Received 6 October 2006, Accepted 12 November 2006)
A one-pot high yielding reductive amination of aldehydes with primary and secondary amines using LiClO4/NaBH4 and LiClO4/LiAlH4 as reducing agents in diethyl ether is described.
Keywords: Reductive amination, Sodium borohydride, Lithium aluminum hydride, Lithium perchlorate, Aldehyde