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Article info. : 2007; 4(2) (pp 126~174)

 

Application of N-Halo Reagents in Organic Synthesis

E. Kolvaria, A. Ghorbani-Choghamaranib, P. Salehic, F. Shirinid and M.A. Zolfigol a,*

aFaculty of Chemistry, Bu-Ali Sina University, Hamedan, 6517838683, Iran

bDepartment of Chemistry, Faculty of Science, Ilam University, Ilam, Iran

cDepartment of Phytochemistry, Medicinal Plants and Drugs Research Institute, Shahid Beheshti University, Evin, Tehran, Iran

dDepartment of Chemistry, Faculty of Science, Guilan University, Rasht, Iran

(Received 11 April 2007, Accepted 1 May 2007)

This review article summarizes published data on the application of N-halo reagents (such as N-halo amines, N-halo amides and/or imides, N-halo sulfonamides and/or imides, and etc.) in various organic functional group transformations such as: oxidation reactions, deprotection and protection of different functional groups, halogenation of saturated and unsaturated compounds, acylation of alcohols, phenols, amines or thiols, epoxidation of alkenes, aziridination and etc. The main purpose of writing this review is encouraging of active researchers interested to this field for the synthesis of new N-halo reagents specially with different halogens and applications of these new N-halo reagents in organic reactions or finding more and more applications of existing N-halo reagents in organic synthesis.

Keywords: N-Halo reagents, N-Halo imides, N-Halo amines, N-Halo sulfonamides, N-Halo amides, N-Halo sulfonimides

 

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