Evaluation of Biological Activities of Some Schiff Bases and Metal Complexes
S. Baluja*, A. Solanki and N. Kachhadia
Department of Chemistry, Saurashtra University Rajkot-360005 (Gujarat), India
(Received 17 May 2006, Accepted 26 June 2006)
Several Schiff bases were synthesised from sulphonamide and resacetophenone. The characterisation was done by CHN analysis, IR and NMR spectral data. These Schiff bases were evaluated for their antimicrobial activity against both Gram-positive and Gram-negative bacteria as well as fungi. The antibacterial activity was studied against B. megaterium, E. coli, B. subtilis, P. fluorescens and antifungal activity against A. awamori. In addition, copper, nickel, cobalt, and iron complexes of two Schiff bases were also synthesised. Their structural characterisation was performed using CHN analysis and IR spectral data and their antibacterial and antifungal activities were also evaluated. The comparison of antimicrobial activities of the ligands and complexes shows that the presence of metal causes more inhibition i.e., more activity. Out of the four metals studied, cobalt and iron were found to have more antimicrobial activity.
Keywords: Antibacterial activity, Metal complexes, Schiff bases