J. Iran. Chem. Soc., Vol. 8, Supp. 1 February 2011, pp.S17~S27.

Current location: JICS Archive > Vol. 8 > Supplement. 1 > Articles : 3

Chemoselective Synthesis of 2-Aryloxazines and 2-Aryltetrahydropyrimidines Using Nano-SiO2 as a Reusable Solid Acid Catalyst under Thermal Conditions and Microwave Irradiation

I. Mohammadpoor-Baltorka,*, M. Moghadama, S. Tangestaninejada, V. Mirkhania, Z. Eskandaria and H. Salavatib

aDepartment of Chemistry, Catalysis Division, University of Isfahan, Isfahan, 81746-73441, Iran
bDepartment of Chemistry, Payame Noor University (PNU), 81395-671, Isfahan, Iran

Nano-SiO2 solid acid efficiently and selectively catalyzed the cyclocondensation reaction of arylnitriles with 3-amino-1-proopanol or 1,3-diaminopropane to afford their respective 2-substituted oxazines and tetrahydropyrimidines in high yields under thermal conditions and microwave irradiation. This methodology works effectively for the selective synthesis of mono-1,3-oxazines and mono-tetrahydropyrimidnes from dinitriles. The catalyst could be recycled and reused several times without a noticeable decrease in its activity.

Keywords: Oxazines, Tetrahydropyrimidines, Microwave irradiation, Nano-SiO2 catalyst, Solvent-free

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