Current location: JICS Archive > Vol. 8 > No. 3 > Articles : 4

One-Pot Synthesis of Functionalized α-Acyloxythioamides fromN-Protected a-Amino Acids as an Acid Component in the Passerini Reaction in an Ionic Liquid

I. Yavari*, A.S. Shahvelayati, M. Ghanbari, M. Ghazvini and M. Piltan

Chemistry Department, Islamic Azad University, Science and Research Branch, Ponak, Tehran, Iran

N-Protected α-amino acids, prepared from benzoyl chlorides, KSCN and α-amino acids, were used as the acid component in the Passerini reaction, in an ionic liquid, to produce functionalized α-acyloxythioamides in 59-95% yields. The work-up procedure was fairly simple and the products did not require further purification.

Keywords: Passerini reaction, Ionic liquid, Carboxylic acid, Alkyl isocyanide, α-Acyloxycarboxathioamide