J. Iran. Chem. Soc., Vol. 8, No. 3 September 2011, pp.687~693.

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A Novel PVC Membrane Sensor for Determination of Loratadine in Pharmaceutical Compounds and Blood Serum

M.H. Mashhadizadeha,*, A. Hadjiakhoondib and S. Ahmadaghaeia

aFaculty of Chemistry, Tarbiat Moallem University, Tehran, Iran
bFaculty of Pharmacy and Medicinal Plants Research Center, Tehran Medical Science University, Tehran, Iran

A novel PVC membrane-selective electrode based on loratadine-tetraphenyl borate ion-pair was prepared for the determination of loratadine potentiometrically. This electrode exhibits a Nernstian slope of 59.1 ± 0.3 mV decade-1 for loratadine in a concentration range of 5.0 × 10-6-1.0 × 10-2 M at pH 2.2 with a detection limit of 2.9 × 10-6 M. The potential of the electrode is very stable and exhibits good reproducibility with very fast response time (~3 s). The selectivity of the proposed electrode towards some cations and organic compounds was tested and the selectivity coefficients were calculated. The electrode was successfully applied to the determination of loratadine in tablets and blood samples.

Keywords: Loratadine, Potentiometric sensor, PVC membrane electrode, Tetraphenyl borate, Pharmaceutical compound

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