J. Iran. Chem. Soc., Vol. 8, No. 2 June 2011, pp.525~530.

Current location: JICS Archive > Vol. 8 > No. 2 > Articles : 17

A Novel One-Pot Synthesis of 2-Alkylthio-1,3,4-oxadiazoles in Water

F. Aryanasab, H. Maleki and M.R. Saidi*

Department of Chemistry, Sharif University of Technology, Tehran, Iran

      A facile and one-pot protocol for the synthesis of 2-alkylthio-1,3,4-oxadiazoles is reported. This green method relies on the reaction of acid hydrazides with CS2 and an alkyl halide.  The reaction is carried out under mild and environmentally friendly procedure in water with high to excellent yields. Thirteen different valuable alkylthio-1,3,4-oxadiazoles are synthesized from cheap and easily available CS2 with this method. This is the first report for the synthesis of 1,3,4-oxadiazoles in water.

Keywords: Alkyl-2-thio-1,3,4-oxadiazoles, Hydrazids, Carbon disulfide, Alkyl halides, Water

Download full-text PDF