J. Iran. Chem. Soc., Vol. 8, No. 2 June 2011, pp.462~469.

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Nafion®NR50 Catalyzed A3-Coupling for the Synthesis of Propargylamines via C-H Activation

M. Kidwai* and A. Jahan

Green Chemistry Research Laboratory, Department of Chemistry, The University of Delhi, Delhi-110007, India

      A one-pot, three-component coupling reaction of aldehydes, amines and alkyne (A3-coupling) via C-H activation using perflorinated resinsulphonic acid (Nafion®NR50) as a recyclable and environmentally benign catalyst for the synthesis of propargylamine derivatives is described. This protocol avoids the use of heavy metals, co-catalysts and produces the propargylamines in excellent yields.

Keywords: A3-Coupling, Nafion�®NR50, Solid acid catalyst, Recyclability, Propargylamines

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