J. Iran. Chem. Soc., Vol. 8, No. 1 March 2011, pp.24~30.

Current location: JICS Archive > Vol. 8 > No. 1 > Articles : 1

A Stereoselective Three-Component Reaction:The Facile Synthesis of Fluorinated Tetrahydropyrimido[1,2-b]benzothiazoles

A. Shaabani*, A. Rahmati, A.H. Rezayan and H.R. Khavasi

Department of Chemistry, Shahid Beheshti University, P.O. Box 19396-4716 Tehran, Iran

     A one-pot, catalyst- and solvent-free approach has been developed for the stereoselective synthesis of fluorinated tetrahydropyrimido[1,2-b]benzothiazoles. The three-component condensation reaction of an aldehyde and a trifluoromethyl β-dicarbonyl compound in the presence of 2-aminobenzothizole occurs in high yields at 90 °C.

Keywords: Fluorinated compound, 2-Aminobenzothizole, 3-Amino-1,2,4-triazole, Solvent-free, Catalyst-free

Download full-text PDF