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A Stereoselective Three-Component Reaction:The Facile Synthesis of Fluorinated Tetrahydropyrimido[1,2-b]benzothiazoles

A. Shaabani*, A. Rahmati, A.H. Rezayan and H.R. Khavasi

Department of Chemistry, Shahid Beheshti University, P.O. Box 19396-4716 Tehran, Iran

     A one-pot, catalyst- and solvent-free approach has been developed for the stereoselective synthesis of fluorinated tetrahydropyrimido[1,2-b]benzothiazoles. The three-component condensation reaction of an aldehyde and a trifluoromethyl β-dicarbonyl compound in the presence of 2-aminobenzothizole occurs in high yields at 90 °C.

Keywords: Fluorinated compound, 2-Aminobenzothizole, 3-Amino-1,2,4-triazole, Solvent-free, Catalyst-free