Saccharin Sulfonic Acid Catalyzed N-Boc Protection of Amines and Formation of tert-Butyl Ethers from Alcohols

F. Shirini^a,, M.A. Zolfigol^b and M. Abedini^a*

^aDepartment of Chemistry, College of Science, University of Guilan, Rasht 41335,
I. R. Iran ^bCollege of Chemistry, Bu-Ali Sina University, Hamadan, I. R. Iran

Saccharin sulfonic acid (SaSA), as a stable reagent is easily prepared by the reaction of saccharin with neat chlorosulfonic acid at room temperature. This compound is able to catalyze conversion of amines to their corresponding N-Boc protected amines with (Boc)₂O. Alcohols were also converted to their corresponding tert-butyl ethers. All reactions took place under mild conditions giving the desired products in good to high yields.

Keywords: Alcohols, Amines, Saccharin sulfonic acid, tert-Butyl ethers, (Boc)₂O

Saccharin Sulfonic Acid Catalyzed N-Boc Protection of Amines and Formation of tert-Butyl Ethers from Alcohols

F. Shirinia,*, M.A. Zolfigolb and M. Abedinia

aDepartment of Chemistry, College of Science, University of Guilan, Rasht 41335, I. R. Iran bCollege of Chemistry, Bu-Ali Sina University, Hamadan, I. R. Iran

F. Shirini^a,, M.A. Zolfigol^b and M. Abedini^a*

^aDepartment of Chemistry, College of Science, University of Guilan, Rasht 41335,
I. R. Iran ^bCollege of Chemistry, Bu-Ali Sina University, Hamadan, I. R. Iran