J. Iran. Chem. Soc., Vol. 7, No. 2 June 2010, pp.333~338.

Current location: JICS Archive > Vol. 7 > No. 2 > Articles : 5

Potentiometric PVC Membrane Sensor for the Determination of Phenylephrine Hydrochloride in Some Pharmaceutical Products

M. Giahia,*, M. Mirzaeib and G. Veghar Lahijania

aDepartment of Chemistry, Faculty of Science, Islamic Azad University, Lahijan Branch, Lahijan, Iran
bDepartment of Chemistry, Tarbiat Modares University, Tehran, Iran

A new PVC membrane electrode for the determination of phenylephrine hydrochloride based on the formation of an ion-association complex of phenylephrine hydrochloride with the phosphotungstate counter anion as an electroactive material dispersed in a PVC matrix is described. The sensor shows a fast, stable, near-Nernstian response for 1.0 × 10-5 to 1.0 × 10-1 M phenylephrine hydrochloride at 25 °C over the pH range of 3.5-8.0 with a cationic slope of 58.1 ± 0.6 mV decade-1. The electrode was successfully used for potentiometric determination of phenylephrine hydrochloride in some pharmaceutical drugs.

Keywords: Ion-pair sensor, Phenylephrine hydrochloride, Potentiometry, PVC-membrane, Selectivity

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