J. Iran. Chem. Soc., Vol. 7, No. 2 June 2010, pp.461~469.

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A Highly Efficient Protocol for the Synthesis of N-Aryl Nucleobases Using Zinc Oxide in Ionic Liquids

A. Zarea,*, A. Hasaninejadb,*, A. Khalafi-Nezhadc, A.R. Moosavi-Zarea, M.H. Beyzavic, F. Khedria, F. Asadia, N. Hayatia and A. Asifia

aDepartment of Chemistry, Payame Noor University (PNU), Iran
bDepartment of Chemistry, Faculty of Sciences, Persian Gulf University, Bushehr 75169, Iran
cDepartment of Chemistry, College of Sciences, Shiraz University, Shiraz 71454, Iran

A highly efficient and simple method for the synthesis of N-aryl derivatives of pyrimidine and purine nucleobases via N-arylation of nucleobases using zinc oxide in 1-butyl-3-methylimidazolium bromide ([bmim]Br) under microwave as well as thermal conditions is described. In both conditions, the title compounds were produced in high to excellent yields and in short reaction times.  

Keywords: N-Aryl nucleobase, Zinc oxide, Ionic liquid, N-Arylation, Microwave

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