Zr(HSO₄)₄Catalyzed One-Pot Strecker Synthesis of α-Amino Nitriles from Aldehydes and Ketones under Solvent-Free Conditions

A.R. Hajipour^a,b,,Y. Ghayeb^band N. Sheikhan^b*

^aDept. of Pharmacology, University of Wisconsin, Medical School, 1300 University Avenue, Madison, 53706-1532, WI, USA
^bPharmaceutical Research Laboratory, College of Chemistry, Isfahan University of Technology, Isfahan 84156, IR Iran

A mild and efficient method has been developed for the preparation of α-amino nitriles from the condensation of aldehydes and ketones with aniline and TMSCN in the presence of a catalytic amount of Zr(HSO₄)₄ under solvent-free conditions at room temperature.

Keywords: Strecker, α-Amino nitriles, Zr(HSO₄)₄,Solid acid

Zr(HSO4)4Catalyzed One-Pot Strecker Synthesis of α-Amino Nitriles from Aldehydes and Ketones under Solvent-Free Conditions

A.R. Hajipoura,b,*, Y. Ghayebb and N. Sheikhanb

aDept. of Pharmacology, University of Wisconsin, Medical School, 1300 University Avenue, Madison, 53706-1532, WI, USA bPharmaceutical Research Laboratory, College of Chemistry, Isfahan University of Technology, Isfahan 84156, IR Iran

Zr(HSO₄)₄Catalyzed One-Pot Strecker Synthesis of α-Amino Nitriles from Aldehydes and Ketones under Solvent-Free Conditions

A.R. Hajipour^a,b,,Y. Ghayeb^band N. Sheikhan^b*

^aDept. of Pharmacology, University of Wisconsin, Medical School, 1300 University Avenue, Madison, 53706-1532, WI, USA
^bPharmaceutical Research Laboratory, College of Chemistry, Isfahan University of Technology, Isfahan 84156, IR Iran