J. Iran. Chem. Soc., Vol. 7, No. 1 March 2010, pp.155~163.

Current location: JICS Archive > Vol. 7 > No. 1 > Articles : 17

In vitro Antitumor and Antibacterial Assay of Organotin(IV) Complexes of 2,3-Methylenedioxybenzoic Acid; X-Ray Crystal Structure of [(C2H5)2Sn(C8H5O4)2]

M. Hussaina, M. Hanifa, S. Alia,*, S. Shahzadib,*, M.S. Ahmadc, B. Mirzac and H.S. Evansd

aDepartment of Chemistry, Quaid-i-Azam University, Islamabad-45320, Pakistan
bDepartment of Chemistry, GC University, Faisalabad, Pakistan
cDepartment of Biochemistry, Quaid-i-Azam University, Islamabad-45320, Pakistan
dInstitute of Microtechnology, University of Neuchatel, Rue Emile-Argand 11, CH-2009 Neuchatel, Switzerland

New organotin(IV) compounds containing the carboxylate ligand 2,3-methylenedioxybenzoic acid (HL) have been synthesized with the general formula R2SnL2 (R = Me, Et, n-Bu, Ph and n-Oct) and R3SnL (R = n-Bu). All compounds have been studied in the solution state by multinuclear NMR (1H, 13C and 119Sn) by using the non-coordinating solvent and also in solid sate by FTIR, mass spectrometry and X-ray crystallography. Spectroscopic data have shown that methylenedioxy moiety does not coordinate with tin atom and the coordination site is actually -COO group, as is proved by X-ray structure determination. The solid state structure of compound (2) has been determined by X-ray crystallography which shows that the complex (2) has distorted octahedral geometry. These complexes have been evaluated in vitro against crown gall tumor and antibacterial activity. Interesting results were noticed during the bio-activity screenings, which proved their in vitro biological potential and possible use as drugs.

Keywords: Organotin(IV) 2,3-methylenedioxy benzoates, Spectroscopy, X-ray structure, Antitumor activity, Antibacterial activity

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