J. Iran. Chem. Soc., Vol. 6, No. 3 September 2009, pp.514~518.

Current location: JICS Archive > Vol. 6 > No. 3 > Articles : 6

NaIO4-Catalyzed One-Pot Synthesis of Dihydropyrimidinones at Room Temperature under Solvent-Free Conditions

X. Jing*, Z. Li, X. Pan, Y. Shi and C. Yan

College of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou 225002, P. R. China

Sodium periodate efficiently catalyzed the three-component Biginelli reaction of an aldehyde, α β-keto ester or β-keto ketone, and urea or thiourea at room temperature under solvent-free conditions and afforded the corresponding 3,4-dihydropyrimidine-2-(1H)-ones in excellent yields.

Keywords: Pyrimidinones, Sodium periodate, Biginelli reaction, Solvent-free conditions

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