J. Iran. Chem. Soc., Vol. 6, No. 3 September 2009, pp.547~551.

Current location: JICS Archive > Vol. 6 > No. 3 > Articles : 11

Green Protocol for Synthesis of the 3,5-Disubstituted 1,2,4-Thiadiazoles Using N-Benzyl-DABCO-Tribromide in Aqueous Media


H. Zali Boeini


Department of Chemistry, University of Isfahan, Isfahan, 81764-73441, Iran


A novel and simple method for rapid conversion of thioamides to the corresponding 1,2,4-thiadiazole derivatives was developed. It was shown that, thioamides undergo clean and efficient oxidation and cyclization in their conversion to 1,2,4-thiadiazoles using N-benzyl-DABCO-tribromide in wet solid-solid conditions.


Keywords: Synthesis, 3,5-Disubstituted 1,2,4-thiadiazoles, N-Benzyl-DABCO-tribromide, Aqueous media

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