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An Efficient Catalyst-Free Ring Opening of Epoxides in PEG-300: A Versatile Method for the Synthesis of Vicinal Azidoalcohols

A.R. Kiasat* and M. Fallah-Mehrjardi

Chemistry Department, Faculty of Sciences, Shahid Chamran University, Ahvaz 61357-4-3169, Iran

Efficient and regioselective conversion of epoxides to 1,2-azidoalcohols has been carried out by treatment of sodium azide using polyethylene glycol as the reaction medium. The reaction afforded the corresponding products with high regioselectivity under mild reaction conditions.

Keywords: 1,2-Azidoalcohol, Epoxide, Polyethylene glycol, Sodium azide, Azidohydrin, Ring opening