J. Iran. Chem. Soc., Vol. 6, No. 1 March 2009, pp.77~81.

Current location: JICS Archive > Vol. 6 > No. 1 > Articles : 3

Syntheses and Antibacterial Studies of Some 2-[5-(Aryl)-[1,3,4]oxadiazole-2-ylsulfanyl] alkanoic Acids

N. Jaina,*, D.P. Pathakb, P. Mishrac and S. Jaind

aJCDM College of Pharmacy, Sirsa-125 055 (Haryana), India
bDelhi Institute of Pharmaceutical Science and Research, New Delhi, India
cDepartment of Pharmaceutical Sciences, Dr. H.S. Gour Vishwavidyalaya Sagar-470 003 (M.P.)
dDepartment of Pharmaceutical Sciences, Guru Jambheshwar University of Science and Technology,Hisar-125 001 (Haryana), India

Some new 2-[5-(aryl)-[1,3,4]oxadiazole-2-ylsulfanyl]alkanoic acids were synthesized and studied for their antibacterial activity. These compounds were prepared from aromatic carboxylic acid hydrazides. Aromatic  carboxylic  acid  hydrazides  1  on  refluxing  with carbon  disulfide  and  methanolic  potassium  hydroxide  and  then  on  subsequent acidification with hydrochloric acid furnish 5-aryl-1,3,4-oxadiazole-2-thiones 2. 2-Chloro alkanoic acids react with 2 in alkaline media and on acidification yield the title compounds 3. These compounds were characterised by CHN analyses, IR, mass and 1H NMR spectral data. All the compounds were  evaluated  for  their  in  vitro  antibacterial activity  against  two  Gram  negative  strains  (Escherichia  coli and Pseudomonas aeruginosa) and two Gram positive strains (Bacillus subtilis and Staphylococcus aureus) and their minimum inhibitory concentration (MIC) were determined.

Keywords: Synthesis, Antibacterial activity, 1,3,4-Oxadiazole derivatives, Minimum inhibitory concentration

Download full-text PDF