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Oxidation of 1,4-Dihydropyridines under Mild and Heterogeneous Conditions Using Solid Acids

M.A. Zolfigol ^a,*, M. Bagherzadeh^b, K. Niknam^c,*, F. Shirini^d, I. Mohammadpoor-Baltork^e, A. Ghorbani Choghamarani^a and M. Baghbanzadeh^a

^aChemistry Department, College of Science, Bu-Ali Sina University, Hamadan 65174, Iran
^bCollege of Chemistry, Sharif University of Technology, Tehran, Iran
^cChemistry Department, Faculty of Sciences, Persian Gulf University, Bushehr 75168 Iran
^dChemistry Department, College of Science, Guilan University, Rasht, Iran
^eChemistry Department, College of Science, Isfahan University, Isfahan, Iran

A combination of solid acids, including Oxone^�®, HIO₃, H₅IO₆, and polystyrenesulfonic acid and sodium nitrite, in the presence of wet SiO₂ were used as an effective oxidizing agents for the oxidation of dihydropyridines to their corresponding pyridine derivatives under mild and heterogeneous conditions in good to excellent yields.

Keywords: Oxidation, 1,4-Dihydropyridines, Pyridines, Solid acids