J. Iran. Chem. Soc., Vol. 1, No. 2 December 2004, pp.159~162.

Current location: JICS Archive > Vol. 1 > No. 2 > Articles : 8

Wet Silica-Supported Permanganate: A Mild and Inexpensive Reagent for Highly Enantiomeric Purity Conversion of α-Sulfinyl Oximes and α-Sulfinyl Hydrazones to α-Keto Sulfoxides

A.R. Hajipour*,a,b and A.E. Ruohoa

a Department of Pharmacology, University of Wisconsin, Medical School, 1300 University Avenue, Madison,WI 53706-1532, USA
b Pharmaceutical Research Laboratory, College of Chemistry, Isfahan University of Technology, Isfahan 84156, IR Iran

Wet silica-supported potassium permanganate was used as an inexpensive and efficient reagent for conversion of α-sulfinyl oximes 1 and α-sulfinyl hydrazones 2 to the corresponding α-keto sulfoxides (3) in high yields and high enantiomeric purity under solvent-free conditions.

Keywords: Deprotection, Wet silica, Solvent-free

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