J. Iran. Chem. Soc., Vol. 1, No. 2 December 2004, pp.136~140.

Current location: JICS Archive > Vol. 1 > No. 2 > Articles : 5

A Novel and Efficient Method for the Synthesis of α-Aminonitriles by the Reaction of Aminals with Trimethylsilyl
Cyanide Catalyzed by Iodine

M.R. Saidi* and N. Azizi

Depatment of Chemistry, Sharif University of Technologhy, P. O. Box 11365- 9516 Tehran, Iran

Iodine, was found to be a practical and novel catalyst for the reaction of aminal and trimethylsilyl cyanide under mild and neutral reaction condition to afford the corresponding α-aminonitriles in high yields and short reaction times. Trimethylsilyl iodide derived in situ from elemental iodine and trimethylsillyl cyanide catalyzed this conversion.

Keywords: Trimethylsilyl cyanide, Carbonyl compounds, Iodine, Iminium salt, Aminal

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