SbCl5.SiO2: an Efficient Alternative for One-Pot Synthesis of 1,2,4,5-Tetrasubstituted Imidazoles in Solvent or under Solvent-Free Condition
B. Sadeghia,*, B.B.F. Mirjalilib, S. Bidakia and M. Ghasemkhania
aDepartment of Chemistry, Islamic Azad University, Yazd Branch, P.O. Box 89195-155, Yazd, Iran
bDepartment of Chemistry, College of Science, Yazd University, P.O. Box 89195-741, Yazd, Iran
In a one-pot four-component reaction, an aldehyde, an amine, benzil and ammonium acetate were condensed for the synthesis of 1,2,4,5-tetrasubstituted imidazoles in the presence of silica supported antimony pentachloride (SbCl5.SiO2) in improved yields. The catalyst is recoverable by simple filtration and can be used in the subsequent reactions.
Keywords: 1,2,4,5-Tetrasubstituted imidazoles, SbCl5.SiO2, Benzil, One-pot synthesis, Aldehyde