Microwave-Assisted Neat Reaction Technology for Regioselective Thiocyanation of Substituted Anilines and Indoles in Solid Media
Y.L.N. Murthya,*, B. Govindha, B.S. Diwakara, K. Nagalakshmia and R. Venub
aOrganic Research Labs, Department of Organic Chemistry, Andhra University, Visakhapatnam-530 003, India
bDepartment of Materials Science and Engineering, Chungnam National University, Daejeon-305764, South Korea
An efficient and solvent -free approach for regioselective thiocyanation of various substituted anilines and indoles is described. The reaction performed both on and off the alumina surface under microwave conditions. Microwave irradiation reactions under solvent-free conditions resulted in a “green-chemistry” procedure, by which thiocyanation was achieved. In comparison to other reported methods for regioselective thiocyanation of anilines and indoles on the focus of reaction times, yields and usage of oxidizing agents, the present method shows considerable advantages.
Keywords: Solvent-free, Regioselective thiocyanation, Microwave irradiation, Anilines, Indoles