A New and Convenient Method for Synthesis of Barbituric Acid Derivatives
A. Habibi* and Z. Tarameshloo
Faculty of Chemistry, Tarbiat Moallem University, No. 49, P. Code 15719-14911, Mofateh Avenue, Tehran, Iran
In continuation of our current studies on the reaction between isocyanides and electron-defficient alkenes, we would like to report our recent reseaarch on synthesizing novel derivatives of barbituric acid. The reaction of alkylidene-substituted Meldrum's acid with alkyl isocyanides in the presence of urea led to the production of the corresponding 2-(hexahydro-2,4,6-trioxopyrimidin-5-yl)-N,2-dimethylpropanamide in good to high yields. The structure of the products was in agreement with their spectroscopic data .
Keywords: Isocyanide, Multi-component reaction, Barbituric acid, Alkylidene-substituted Meldrum’s acid