Zn(OAc)2 Catalyzed Microwave Irradiated Synthesis of Substituted Thieno[2, 3-d]pyrimidin-4(3H)-one
X. Jinga,*, Z. Lib, L. Wua and C. Yana
aCollege of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou 225002, P. R. China
bDepartment of Chemistry, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Fudan University, Shanghai 200433, People’s Republic of China
Different Lewis acids were screened to catalyze the reaction of 2-amino-thiophene-3-carboxylate, orthoformate and aryl amine to form 2-substituted thieno[2,3-d]pyrimidin-4(3H)-one. Zn(OAc)2 was demonstrated to efficiently catalyze the reaction. 20 substituted thieno[2,3-d]pyrimidines were synthesized by adding 0.5% mol Zn(OAc)2 as catalyst under microwave irradiation.
Keywords: Thienopyrimidine, Microwave irradiation, Zn(OAc)2, Catalyze