J. Iran. Chem. Soc., Vol. 6, No. 3 September 2009, pp.588~593.
Current location: JICS Archive > Vol. 6 > No. 3 > Articles : 15
A Highly Efficient Michael Addition of Indoles to α,β-Unsaturated Electron-Deficient Compounds in Acidic SDS Micellar Media
A.A. Jafari*, F. Moradgholi and F. Tamaddon
Department of Chemistry, Faculty of Science, Yazd University, Yazd 89195-741, Iran
The Michael addition of indoles to α,β-unsaturated electron deficient compounds was catalyzed efficiently at room temperature in acidic micellar solution of sodium dodecyl sulfate (SDS). The substitution on the indole nucleus occurred exclusively at the 3-position in good to excellent yields, and no N-alkylation products were observed.
Keywords: Michael addition, Indole, α,β-Unsaturated electron-deficient compounds, Micellar media
