Methyl Triphenylphosphonium Peroxydisulfate (MTPPP): A Mild and Inexpensive Reagent for the Cleavage of Oximes, Phenylhydrazones and 2,4-Dinitro phenylhydrazones to the Corresponding Carbonyl Compounds Under Non-Aqueous Conditions

A.R. Hajipour^a,b, S. Zahmatkesh^a and A.E. Ruoho^b*

^aPharmaceutical Research Laboratory, Department of Chemistry, Isfahan University of Technology, Isfahan, Iran.
^bDept. of Pharmacology, University of Wisconsin Med. Sci, 1300 University Avenue, Madison, WI, USA

Methyltriphenylphosphonium peroxydisulfate (MTPPP) was synthesized by treating methyltriphenylphosphonium bromide with potassium peroxydisulfate in aqueous solution. This reagent was used as a suitable and efficient reagent for the cleavage of oximes, phenylhydrazones and 2,4-dinitro phenylhydrazones to their corresponding carbonyl compounds under non-aqueous condition.

Keywords: Deprotection, Oxidative cleavage, Carbonyl compounds, Phosphonium salts.

Methyl Triphenylphosphonium Peroxydisulfate (MTPPP): A Mild and Inexpensive Reagent for the Cleavage of Oximes, Phenylhydrazones and 2,4-Dinitro phenylhydrazones to the Corresponding Carbonyl Compounds Under Non-Aqueous Conditions

A.R. Hajipoura,b *, S. Zahmatkesha and A.E. Ruohob

aPharmaceutical Research Laboratory, Department of Chemistry, Isfahan University of Technology, Isfahan, Iran. bDept. of Pharmacology, University of Wisconsin Med. Sci, 1300 University Avenue, Madison, WI, USA

A.R. Hajipour^a,b, S. Zahmatkesh^a and A.E. Ruoho^b*

^aPharmaceutical Research Laboratory, Department of Chemistry, Isfahan University of Technology, Isfahan, Iran.
^bDept. of Pharmacology, University of Wisconsin Med. Sci, 1300 University Avenue, Madison, WI, USA