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Quaternary Ammonium Salts as Highly Efficient and Green Alkylating Agents for N-Alkylation of Azaheterocycles under Microwave Irradiation

A. Khalafi-Nezhad^a, *, A. Zare^b, *, A. Parhami^a, A. Hasaninejad^c and A.R. Moosavi Zare^a

^a Department of Chemistry, College of Sciences, Shiraz University, Shiraz 71454, Iran
^b Department of Chemistry, College of Sciences, Payame Noor University (PNU), Iran
^cDepartment of Chemistry, Faculty of Sciences, Persian Gulf University, Bushehr 75169, Iran

An efficient, simple and green procedure for N-alkylation of azaheterocycles by quaternary ammonium salts in the presence of K₂CO₃ under microwave irradiation is described. Using this method, N-alkyl derivatives of azaheterocycles are obtained in good to excellent yields and short reaction times.

Keywords: Quaternary ammonium salt, N-Alkylation, Azaheterocycle, Microwave, Green chemistry