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An Efficient and General Procedure for Room-Temperature Synthesis of Benzofurans under Solvent-Free Conditions Using KF/Al₂O₃

A. Sharifi*, M.S. Abaee, A. Tavakkoli and M. Mirzaei

Faculty of Organic Chemistry and Natural Products, Chemistry & Chemical Engineering Research Center of Iran, Tehran, Iran

Room temperature Rap-Stoermer condensation of α-haloacetophenone with various 2-hydroxyarylaldehydes mediated by KF/Al₂O₃ resulted in sole formation of good to excellent yields of various substituted benzofurans in the absence solvent or extra stimulant.

Keywords: Benzofuran, Rap-Stoermer reaction, KF/Al₂O₃, Solvent-free