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One-Pot Synthesis of 1-Aminophosphinic Acids Using 50% Hypophosphorus Acid under Microwave Irradiation

B. Kaboudin* and E. Jafari

Department of Chemistry, Institute for Advanced Studies in Basic Sciences (IASBS), Gava Zang, Zanjan, Iran

A simple and efficient method has been developed for the synthesis of α-aminophosphinic acids from hypophosphorus acid under solvent "free conditions using microwave irradiation. α-Aminophosphinic acids were obtained in high yield under mild conditions by reaction of hypophosphorus acid with aldehydes in the presence of amines under microwave irradiation.

Keywords: Addition reaction, Aldehydes, Amines, 1-Aminophosphinic acids, Microwave-assisted