Current location: JICS Archive > Vol. 5 > Supplement. 1 > Articles : 11

Tetrabutylammonium Bromide Promoted Efficient and Chemoselective Trimethylsilylation of Primary and Secondary Alcohols Under Mild Reaction Conditions

F. Shirini* and M. Abedini

Department of Chemistry, College of Science, The University of Guilan, Rasht

A mild and efficient method for trimethylsilylation of alcohols with hexamethyldisilazane (HMDS) catalyzed by tetrabutylammonium bromide is reported. The method is highly chemoselective for the o-protection of primary and secondary alcohols in the presence of amines, thiols and tertiary alcohols.

Keywords: Alcohols, Trimethylsilylation, Tetrabutylammonium bromide, Chemoselective, Hexamethyldisilazane