LiAlH₄/Silica Chloride as a New Chemoselective System for Reduction of Carbonyl Compounds and Phosphine Oxides

M.A. Khalilzadeh^a,, A. Hosseini^a, M. Tajbakhsh ^a and F. Mohannazadeh^b*

^aDepartment of Chemistry, Islamic Azad University, Qaemshahr, Iran
^bInstitute of Industrial Chemistry, Iranian Research Organization for Science and Technology, Tehran, Iran

LiAlH₄/silica chloride system was used as an efficient and chemoselective reductant for organic substrates. The reduction of phosphine oxides was achieved with this system. Good chemoselectivity in reduction of aldehydes and ketones in the presence of other carbonyl compounds was observed.

Keywords: Lithium aluminium hydride, Silica chloride, Reduction, Carbonyl compounds, Phosphine oxides

LiAlH4/Silica Chloride as a New Chemoselective System for Reduction of Carbonyl Compounds and Phosphine Oxides

M.A. Khalilzadeha,*, A. Hosseinia, M. Tajbakhsh a and F. Mohannazadehb

aDepartment of Chemistry, Islamic Azad University, Qaemshahr, Iran bInstitute of Industrial Chemistry, Iranian Research Organization for Science and Technology, Tehran, Iran

LiAlH₄/Silica Chloride as a New Chemoselective System for Reduction of Carbonyl Compounds and Phosphine Oxides

M.A. Khalilzadeh^a,, A. Hosseini^a, M. Tajbakhsh ^a and F. Mohannazadeh^b*

^aDepartment of Chemistry, Islamic Azad University, Qaemshahr, Iran
^bInstitute of Industrial Chemistry, Iranian Research Organization for Science and Technology, Tehran, Iran