An Efficient Solventless Method for the Synthesis of N,N-Dialkyl Sulfonamide Derivatives

A. Zare^a,, A. Hasaninejad^b,, A.R. Moosavi Zare^c, A. Khalafi-Nezhad^c and A. Parhami^c

^aDepartment of Chemistry, College Sciences, Payame Noor University, Iran
^bDepartment of Chemistry, Faculty of Sciences, Persian Gulf University, Bushehr 75169, Iran
^cDepartment of Chemistry, College of Sciences, Shiraz University, Shiraz 71454, Iran

Aza-Michael addition of sulfonamides to α±,β-unsaturated esters efficiently proceeds in the presence of catalytic amount of sodium hydroxide (NaOH) and tetrabutylammonium bromide (TBAB) as a phase-transfer catalyst (PTC) under microwave irradiation to afford N,N-dialkyl sulfonamides as biologically interesting compounds in good to excellent yields and short reaction times.

Keywords: N,N-Dialkyl sulfonamide, Solvent-free, Michael addition, α,β-Unsaturated ester, NaOH, Microwave

An Efficient Solventless Method for the Synthesis of N,N-Dialkyl Sulfonamide Derivatives

A. Zarea,*, A. Hasaninejadb,*, A.R. Moosavi Zarec, A. Khalafi-Nezhadc and A. Parhamic

aDepartment of Chemistry, College Sciences, Payame Noor University, Iran bDepartment of Chemistry, Faculty of Sciences, Persian Gulf University, Bushehr 75169, Iran cDepartment of Chemistry, College of Sciences, Shiraz University, Shiraz 71454, Iran

A. Zare^a,, A. Hasaninejad^b,, A.R. Moosavi Zare^c, A. Khalafi-Nezhad^c and A. Parhami^c

^aDepartment of Chemistry, College Sciences, Payame Noor University, Iran
^bDepartment of Chemistry, Faculty of Sciences, Persian Gulf University, Bushehr 75169, Iran
^cDepartment of Chemistry, College of Sciences, Shiraz University, Shiraz 71454, Iran