Efficient Method for the Direct Preparation of Aryl Carboxylates from Carboxylic Acids Using Tosyl Chloride Under Solvent-Free Conditions

A. Khalafi-Nezhad^a,, A. Parham^a, A. Zare^b and A.R. Moosavi Zare^a*

^aDepartment of Chemistry, College of Sciences, Shiraz University, Shiraz 71454, Iran
^bDepartment of Chemistry, Payame Nour University of Bushehr, Bushehr 1698, Iran

A simple, clean and efficient solvent-free procedure for the preparation of aryl carboxylates is described from the direct reaction of carboxylic acids and phenols, in the presence of 1-methylimidazole as base and tosyl chloride (TsCl) as coupling agent. This method can be easily applied for different substituted phenols and carboxylic acids. It can also be applied for the selective acylation when other functional group such as hydroxyl is present on phenol ring.

Keywords: Aryl carboxylate, Carboxylic acid, Tosyl chloride, Solvent-free, 1-Methylimidazole

Efficient Method for the Direct Preparation of Aryl Carboxylates from Carboxylic Acids Using Tosyl Chloride Under Solvent-Free Conditions

A. Khalafi-Nezhada,*, A. Parhama, A. Zareb and A.R. Moosavi Zarea

aDepartment of Chemistry, College of Sciences, Shiraz University, Shiraz 71454, Iran bDepartment of Chemistry, Payame Nour University of Bushehr, Bushehr 1698, Iran

A. Khalafi-Nezhad^a,, A. Parham^a, A. Zare^b and A.R. Moosavi Zare^a*

^aDepartment of Chemistry, College of Sciences, Shiraz University, Shiraz 71454, Iran
^bDepartment of Chemistry, Payame Nour University of Bushehr, Bushehr 1698, Iran