Silica Sulfuric Acid as an Efficient Catalyst for the Friedländer Quinoline Synthesis from Simple Ketones and ortho-Aminoaryl Ketones Under Microwave Irradiation

M.A. Zolfigol^a,, P. Salehi^b, M. Shiri^a, T. Faal Rastegar^a and A. Ghaderi^a*

^aFaculty of Chemistry, Bu-Ali Sina University, Hamedan 6517838683, Iran
^bDepartment of Phytochemistry, Medicinal Plants and Drugs Research Institute, Shahid Beheshti University, Evin, Tehran 1983963113, Iran

The synthesis of quinoline derivatives via Friedländer method from ortho-aminoaryl ketones in the presence of a catalytic amount of silica sulfuric acid (SSA) under solvent-free condition and microwave irradiation was described. A good range of simple ketones such as cyclohexanone and deoxybenzoin were used.

Keywords: Quinolines, Friedlander method, ortho-Aminoaryl ketones, Ketones, Silica sulfuric acid

Silica Sulfuric Acid as an Efficient Catalyst for the Friedländer Quinoline Synthesis from Simple Ketones and ortho-Aminoaryl Ketones Under Microwave Irradiation

M.A. Zolfigola,*, P. Salehib, M. Shiria, T. Faal Rastegara and A. Ghaderia

aFaculty of Chemistry, Bu-Ali Sina University, Hamedan 6517838683, Iran bDepartment of Phytochemistry, Medicinal Plants and Drugs Research Institute, Shahid Beheshti University, Evin, Tehran 1983963113, Iran

M.A. Zolfigol^a,, P. Salehi^b, M. Shiri^a, T. Faal Rastegar^a and A. Ghaderi^a*

^aFaculty of Chemistry, Bu-Ali Sina University, Hamedan 6517838683, Iran
^bDepartment of Phytochemistry, Medicinal Plants and Drugs Research Institute, Shahid Beheshti University, Evin, Tehran 1983963113, Iran