J. Iran. Chem. Soc., Vol. 5, No. 2 June 2008, pp.262~267.
Current location: JICS Archive > Vol. 5 > No. 2 > Articles : 5
Synthesis and Biological Study of Novel Bis-chalcones, Bis-thiazines and Bis-pyrimidines
A. Nagaraj and C. Sanjeeva Reddy*
Department of Chemistry, Kakatiya University, Warangal-506009, Andhra Pradesh, India
A series of novel bis-chalcones 3 were prepared by the reaction of 5,5'-methylene-bis-salicylaldehyde 2 with various acetophenones, subsequent treatment of 3 with thiourea or guanidine resulted to the corresponding bis-thiazines or bis-pyrimidines in good yields. All the new compounds have been characterized by IR, 1H NMR, MS and elemental analysis. The antibacterial, antifungal and anti-inflammatory activities of the compounds have also been evaluated.
Keywords: Bis-chalcones, Bis-thiazines, Bis-pyrimidines, 5,5'-Methylene-bis-salicylaldehyde
