Current location: JICS Archive > Vol. 5 > No. 1 > Articles : 6

A Convenient, Rapid and Eco-Friendly Synthesis of Isoxazoline Heterocyclic Moiety Containing Bridge at 2°-Amine as Potential Pharmacological Agent

J.T. Desai*, C.K. Desai and K.R. Desai*

Department of Chemistry, Veer Narmad South Gujarat University, Udhna-Magdalla Road, Surat (West) - 395007, Gujarat State, India

2-Amino-4-(coumarin-3-yl)-thiazole (1) reacted with acetyl chloride gives compound (2) which on further refluxed with various aromatic aldehydes gives compound (3a-j). Thus obtained (3a-j) on further condensed with NH₄OH.HCl using NaOH as a catalyst afforded isoxazoles (4a-j). All the synthesized compounds characterized on the basis of the IR, ¹H NMR, ¹³C NMR and elemental analysis. All the compounds have been screened for antibacterial activity against bacteria (Gram + ve) & (Gram - ve) and antifungal activity.

Keywords: Coumarin, Thiazole, Isoxazole, Microwave technique, Antimicrobial activity evaluation