Solvent-Free Synthesis of Dihydropyrimidinones Catalyzed by Alumina Sulfuric Acid at Room Temperature

S. Besoluk^a, M. Kucukislamoglu^b,, M. Nebioglu^b, M. Zengin^b and M. Arslan^b*

^aSakarya University, Faculty of Education, Department of Science Education, 54300, Sakarya, Turkey
^bSakarya University, Faculty of Arts and Sciences, Department of Chemistry, 54100 Sakarya, Turkey

A simple, efficient and practical procedure for the Biginelli reaction using alumina sulfuric acid (ASA) as a novel acid catalyst is described under solvent-free conditions. The catalyst exhibited remarkable reactivity at room temperature. The method offers several advantages including high yields, environmentally friendly procedure, short reaction times and simple work up procedure.

Keywords: Biginelli reaction, Alumina sulfuric acid, Solvent-free, Dihydropyrimidinones, Room temperature

Solvent-Free Synthesis of Dihydropyrimidinones Catalyzed by Alumina Sulfuric Acid at Room Temperature

S. Besoluka, M. Kucukislamoglub,*, M. Nebioglub, M. Zenginb and M. Arslanb

aSakarya University, Faculty of Education, Department of Science Education, 54300, Sakarya, Turkey bSakarya University, Faculty of Arts and Sciences, Department of Chemistry, 54100 Sakarya, Turkey

S. Besoluk^a, M. Kucukislamoglu^b,, M. Nebioglu^b, M. Zengin^b and M. Arslan^b*

^aSakarya University, Faculty of Education, Department of Science Education, 54300, Sakarya, Turkey
^bSakarya University, Faculty of Arts and Sciences, Department of Chemistry, 54100 Sakarya, Turkey